,
Sylvain Beourou,
Djibiliour Sanogo,
Jean David N’guessan,
Koffi Barthelemy Attioua,
Augustin Amissa Adima
Recipes based on medicinal plants are frequently used to treat malaria in Ivory Coast. Among these recipes is Ahoutou, made from a mixture of the leaves of three plants, one of the most widely used in the village of Djahakro in the commune of Yamoussoukro. However, the use of medicinal plant-based recipes in the fight against malaria must be based on scientific evidence of safety, efficacy and quality. The aim of this study is to provide a scientific, phytochemical and pharmacological basis for the traditional therapeutic use of Ahoutou. To this end, a phytochemical study of the Ahoutou extract was carried out, the antioxidant activity was assessed using the DPPH test and then the in vitro anti-plasmodial activity was carried out on clinical isolates and on the reference strain Dd2. The phytochemical study revealed the presence of polyphenols, flavonoids, alkaloids, tannins, saponins, steroids and triterpenes. The antioxidant activity test showed that Ahoutou was capable of reducing the DPPH free radical. Ahoutou showed promising anti-plasmodial activity (IC50 =12.86 µg/mL) in the clinical strain and moderate activity (IC50 =23.40 µg/mL) in the reference strain. Our results would justify the use of this recipe in the treatment of malaria. We plan to study the toxicity of Ahoutou.
| Published in | Science Journal of Chemistry (Volume 12, Issue 5) |
| DOI | 10.11648/j.sjc.20241205.14 |
| Page(s) | 109-116 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Ahoutou, Antioxidant, Antiplasmodial Activity
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APA Style
Bohui, G. S., Beourou, S., Sanogo, D., N’guessan, J. D., Attioua, K. B., et al. (2024). Phytochemical Screening and Evaluation of the Antioxidant and Antiplasmodial Activities of "Ahoutou", a Recipe Used in the Treatment of Malaria in Ivory Coast. Science Journal of Chemistry, 12(5), 109-116. https://doi.org/10.11648/j.sjc.20241205.14
ACS Style
Bohui, G. S.; Beourou, S.; Sanogo, D.; N’guessan, J. D.; Attioua, K. B., et al. Phytochemical Screening and Evaluation of the Antioxidant and Antiplasmodial Activities of "Ahoutou", a Recipe Used in the Treatment of Malaria in Ivory Coast. Sci. J. Chem. 2024, 12(5), 109-116. doi: 10.11648/j.sjc.20241205.14
AMA Style
Bohui GS, Beourou S, Sanogo D, N’guessan JD, Attioua KB, et al. Phytochemical Screening and Evaluation of the Antioxidant and Antiplasmodial Activities of "Ahoutou", a Recipe Used in the Treatment of Malaria in Ivory Coast. Sci J Chem. 2024;12(5):109-116. doi: 10.11648/j.sjc.20241205.14
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Download@article{10.11648/j.sjc.20241205.14,
author = {Gouegoui Serge-Pacome Bohui and Sylvain Beourou and Djibiliour Sanogo and Jean David N’guessan and Koffi Barthelemy Attioua and Augustin Amissa Adima},
title = {Phytochemical Screening and Evaluation of the Antioxidant and Antiplasmodial Activities of "Ahoutou", a Recipe Used in the Treatment of Malaria in Ivory Coast
},
journal = {Science Journal of Chemistry},
volume = {12},
number = {5},
pages = {109-116},
doi = {10.11648/j.sjc.20241205.14},
url = {https://doi.org/10.11648/j.sjc.20241205.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjc.20241205.14},
abstract = {Recipes based on medicinal plants are frequently used to treat malaria in Ivory Coast. Among these recipes is Ahoutou, made from a mixture of the leaves of three plants, one of the most widely used in the village of Djahakro in the commune of Yamoussoukro. However, the use of medicinal plant-based recipes in the fight against malaria must be based on scientific evidence of safety, efficacy and quality. The aim of this study is to provide a scientific, phytochemical and pharmacological basis for the traditional therapeutic use of Ahoutou. To this end, a phytochemical study of the Ahoutou extract was carried out, the antioxidant activity was assessed using the DPPH test and then the in vitro anti-plasmodial activity was carried out on clinical isolates and on the reference strain Dd2. The phytochemical study revealed the presence of polyphenols, flavonoids, alkaloids, tannins, saponins, steroids and triterpenes. The antioxidant activity test showed that Ahoutou was capable of reducing the DPPH free radical. Ahoutou showed promising anti-plasmodial activity (IC50 =12.86 µg/mL) in the clinical strain and moderate activity (IC50 =23.40 µg/mL) in the reference strain. Our results would justify the use of this recipe in the treatment of malaria. We plan to study the toxicity of Ahoutou.
},
year = {2024}
}
TY - JOUR T1 - Phytochemical Screening and Evaluation of the Antioxidant and Antiplasmodial Activities of "Ahoutou", a Recipe Used in the Treatment of Malaria in Ivory Coast AU - Gouegoui Serge-Pacome Bohui AU - Sylvain Beourou AU - Djibiliour Sanogo AU - Jean David N’guessan AU - Koffi Barthelemy Attioua AU - Augustin Amissa Adima Y1 - 2024/09/26 PY - 2024 N1 - https://doi.org/10.11648/j.sjc.20241205.14 DO - 10.11648/j.sjc.20241205.14 T2 - Science Journal of Chemistry JF - Science Journal of Chemistry JO - Science Journal of Chemistry SP - 109 EP - 116 PB - Science Publishing Group SN - 2330-099X UR - https://doi.org/10.11648/j.sjc.20241205.14 AB - Recipes based on medicinal plants are frequently used to treat malaria in Ivory Coast. Among these recipes is Ahoutou, made from a mixture of the leaves of three plants, one of the most widely used in the village of Djahakro in the commune of Yamoussoukro. However, the use of medicinal plant-based recipes in the fight against malaria must be based on scientific evidence of safety, efficacy and quality. The aim of this study is to provide a scientific, phytochemical and pharmacological basis for the traditional therapeutic use of Ahoutou. To this end, a phytochemical study of the Ahoutou extract was carried out, the antioxidant activity was assessed using the DPPH test and then the in vitro anti-plasmodial activity was carried out on clinical isolates and on the reference strain Dd2. The phytochemical study revealed the presence of polyphenols, flavonoids, alkaloids, tannins, saponins, steroids and triterpenes. The antioxidant activity test showed that Ahoutou was capable of reducing the DPPH free radical. Ahoutou showed promising anti-plasmodial activity (IC50 =12.86 µg/mL) in the clinical strain and moderate activity (IC50 =23.40 µg/mL) in the reference strain. Our results would justify the use of this recipe in the treatment of malaria. We plan to study the toxicity of Ahoutou. VL - 12 IS - 5 ER -
Department of Physics Chemistry, Felix Houphouet-Boigny University, Abidjan, Ivory Coast
Department of Parasitology-Mycology and Malariology Unit, Pasteur Institute in Ivory Coast, Abidjan, Ivory Coast
Department of Physics Chemistry, Felix Houphouet-Boigny University, Abidjan, Ivory Coast
Department of Biochemistry and Pharmacodynamics, Felix Houphouët-Boigny University, Abidjan, Ivory Coast
Department of Physics Chemistry, Felix Houphouet-Boigny University, Abidjan, Ivory Coast
Department of Agro-Food Chemical Engineering, National Polytechnic Institute Felix Houphouet-Boigny, Yamoussoukro, Ivory Coast
