Medicinal plants containing potent bioactive compound effective in treating many diseases exert different pharmacological action. This study designed to evaluate the cytotoxic and thrombolytic activity of Acacia rugata of Mimosaceae family. The cytotoxic and thrombolytic activity was evaluated by brine-shrimp lethality bioassay and in-vitro clot lysis method. Methanol, petroleum-ether, n-hexane, chloroform and dichloromethane fraction leaves (MEL, PETFL, n-HxFL, CHFL, DCMFL), methanol and n-hexane fraction of fruits (MEF, n-HxFF) and methanol fraction of bark (MEB) were used to evaluate cytotoxicity of the plant. Each extracts showed significant cytotoxic property. The LC50 values of MEL, PETFL, n-HxFL, CHFL, DCMFL, MEF, n-HxFF, MEB were observed 1.436, 0.039, 0.974, 0.626, 0.121, 0.176, 0.865, 0.081 µg/ml when compared to standard vincristine (positive control) which LC50 value was 0.049 µg/ml. In thrombolytic activity evaluation 20 mg/ml, 10 mg/ml, 5 mg/ml and 2.5 mg/ml dose of MEL showed 40.52 ± 2.91, 35.09 ± 2.71, 31.96 ± 2.02 and 24.91 ± 3.05% clot lysis respectively while 0.9% NaCl solution (negative control) and standard streptokinase (positive control) exhibited 7.41 ± 1.73% and 48.91 ± 3.52% of clot lysis. It can be assumed that different solvent extracts of A. rugata have important cytotoxic and thrombolytic activity as compared to standard compounds.
| Published in | Journal of Plant Sciences (Volume 8, Issue 1) |
| DOI | 10.11648/j.jps.20200801.12 |
| Page(s) | 12-16 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2020. Published by Science Publishing Group |
Cytotoxic, Thrombolytic, Streptokinase, Vincristine, % of Clot Lysis, Acacia rugata
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APA Style
Bibi Humayra Khanam, Ahmed Rakib, Farhana Binta Faiz, Md. Giash Uddin, Mohammed Kamrul Hossain, et al. (2020). Highly Anticancer and Moderate Thrombolytic Property of Accacia rugata of Mimosaceae Family. Journal of Plant Sciences, 8(1), 12-16. https://doi.org/10.11648/j.jps.20200801.12
ACS Style
Bibi Humayra Khanam; Ahmed Rakib; Farhana Binta Faiz; Md. Giash Uddin; Mohammed Kamrul Hossain, et al. Highly Anticancer and Moderate Thrombolytic Property of Accacia rugata of Mimosaceae Family. J. Plant Sci. 2020, 8(1), 12-16. doi: 10.11648/j.jps.20200801.12
AMA Style
Bibi Humayra Khanam, Ahmed Rakib, Farhana Binta Faiz, Md. Giash Uddin, Mohammed Kamrul Hossain, et al. Highly Anticancer and Moderate Thrombolytic Property of Accacia rugata of Mimosaceae Family. J Plant Sci. 2020;8(1):12-16. doi: 10.11648/j.jps.20200801.12
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Download@article{10.11648/j.jps.20200801.12,
author = {Bibi Humayra Khanam and Ahmed Rakib and Farhana Binta Faiz and Md. Giash Uddin and Mohammed Kamrul Hossain and Ramiz Ahmed Sultan},
title = {Highly Anticancer and Moderate Thrombolytic Property of Accacia rugata of Mimosaceae Family},
journal = {Journal of Plant Sciences},
volume = {8},
number = {1},
pages = {12-16},
doi = {10.11648/j.jps.20200801.12},
url = {https://doi.org/10.11648/j.jps.20200801.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jps.20200801.12},
abstract = {Medicinal plants containing potent bioactive compound effective in treating many diseases exert different pharmacological action. This study designed to evaluate the cytotoxic and thrombolytic activity of Acacia rugata of Mimosaceae family. The cytotoxic and thrombolytic activity was evaluated by brine-shrimp lethality bioassay and in-vitro clot lysis method. Methanol, petroleum-ether, n-hexane, chloroform and dichloromethane fraction leaves (MEL, PETFL, n-HxFL, CHFL, DCMFL), methanol and n-hexane fraction of fruits (MEF, n-HxFF) and methanol fraction of bark (MEB) were used to evaluate cytotoxicity of the plant. Each extracts showed significant cytotoxic property. The LC50 values of MEL, PETFL, n-HxFL, CHFL, DCMFL, MEF, n-HxFF, MEB were observed 1.436, 0.039, 0.974, 0.626, 0.121, 0.176, 0.865, 0.081 µg/ml when compared to standard vincristine (positive control) which LC50 value was 0.049 µg/ml. In thrombolytic activity evaluation 20 mg/ml, 10 mg/ml, 5 mg/ml and 2.5 mg/ml dose of MEL showed 40.52 ± 2.91, 35.09 ± 2.71, 31.96 ± 2.02 and 24.91 ± 3.05% clot lysis respectively while 0.9% NaCl solution (negative control) and standard streptokinase (positive control) exhibited 7.41 ± 1.73% and 48.91 ± 3.52% of clot lysis. It can be assumed that different solvent extracts of A. rugata have important cytotoxic and thrombolytic activity as compared to standard compounds.},
year = {2020}
}
TY - JOUR T1 - Highly Anticancer and Moderate Thrombolytic Property of Accacia rugata of Mimosaceae Family AU - Bibi Humayra Khanam AU - Ahmed Rakib AU - Farhana Binta Faiz AU - Md. Giash Uddin AU - Mohammed Kamrul Hossain AU - Ramiz Ahmed Sultan Y1 - 2020/04/07 PY - 2020 N1 - https://doi.org/10.11648/j.jps.20200801.12 DO - 10.11648/j.jps.20200801.12 T2 - Journal of Plant Sciences JF - Journal of Plant Sciences JO - Journal of Plant Sciences SP - 12 EP - 16 PB - Science Publishing Group SN - 2331-0731 UR - https://doi.org/10.11648/j.jps.20200801.12 AB - Medicinal plants containing potent bioactive compound effective in treating many diseases exert different pharmacological action. This study designed to evaluate the cytotoxic and thrombolytic activity of Acacia rugata of Mimosaceae family. The cytotoxic and thrombolytic activity was evaluated by brine-shrimp lethality bioassay and in-vitro clot lysis method. Methanol, petroleum-ether, n-hexane, chloroform and dichloromethane fraction leaves (MEL, PETFL, n-HxFL, CHFL, DCMFL), methanol and n-hexane fraction of fruits (MEF, n-HxFF) and methanol fraction of bark (MEB) were used to evaluate cytotoxicity of the plant. Each extracts showed significant cytotoxic property. The LC50 values of MEL, PETFL, n-HxFL, CHFL, DCMFL, MEF, n-HxFF, MEB were observed 1.436, 0.039, 0.974, 0.626, 0.121, 0.176, 0.865, 0.081 µg/ml when compared to standard vincristine (positive control) which LC50 value was 0.049 µg/ml. In thrombolytic activity evaluation 20 mg/ml, 10 mg/ml, 5 mg/ml and 2.5 mg/ml dose of MEL showed 40.52 ± 2.91, 35.09 ± 2.71, 31.96 ± 2.02 and 24.91 ± 3.05% clot lysis respectively while 0.9% NaCl solution (negative control) and standard streptokinase (positive control) exhibited 7.41 ± 1.73% and 48.91 ± 3.52% of clot lysis. It can be assumed that different solvent extracts of A. rugata have important cytotoxic and thrombolytic activity as compared to standard compounds. VL - 8 IS - 1 ER -
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