Survival Advantage of Non-hispanic White Patients with Pancreatic Head Carcinoma: A Population-based Study

Hongyu Yu; Chengzhuo Li; Qihui Wu; Jukun Su; Ankang Liu; Qiqi Ke; Qiaohong Yang

doi:doi:10.11648/j.ajbls.20210901.18

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Survival Advantage of Non-hispanic White Patients with Pancreatic Head Carcinoma: A Population-based Study

Hongyu Yu, Chengzhuo Li, Qihui Wu, Jukun Su, Ankang Liu, Qiqi Ke, Qiaohong Yang

Published in American Journal of Biomedical and Life Sciences (Volume 9, Issue 1)

Received: 10 January 2021 Accepted: 20 January 2021 Published: 2 February 2021

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Abstract

Numerous studies have shown that racial health disparities in gastroenterology and hepatology, but little is known about its effect on pancreatic head carcinoma (PHC). The aim of the present study was to determine whether racial disparities in the overall survival (OS) and cancer-specific survival (CSS) rates exist among US patients with PHC. The SEER database was searched for US residents who had been diagnosed with PHC from 2007 to 2015. The outcomes for 9724 Hispanic white (HW) patients and their non-Hispanic white (NHW) counterparts were compared using Kaplan-Meier survival and Cox regression analyses. We found that race affected both OS and CSS. The 5-year OS rate was worse for HW patients (45.9%) than for NHW patients (49.6%, P<0.001), as was the 5-year CSS rate (39.8% versus 44.0%, P=0.002). Race appeared to be an independent prognostic factor for PHC in the multivariate analysis, with NHW patients showing superior OS (P=0.007) and CSS (P=0.037) compared with HW patients. Subgroup analysis showed that race influenced survival among patients who received surgery, enjoyed Medicaid, and those at American Joint Committee on Cancer (AJCC) tumor-node-metastasis (TNM) stage II, but not of patients at AJCC TNM stage I, III, or IV and those who did not receive surgery or had no insurance. In short, the survival outcomes for PHC are better for NHW than HW patients. The survival advantage is more skewed towards NHW patients than HW patients with PHC, so culturally appropriate interventions, strengthened preventive services, and additional financial support should focus more on HWs.

Published in	American Journal of Biomedical and Life Sciences (Volume 9, Issue 1)
DOI	10.11648/j.ajbls.20210901.18
Page(s)	58-68
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Pancreatic Head Carcinoma, Survival Advantage, SEER, OS, CSS

References

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Hongyu Yu, Chengzhuo Li, Qihui Wu, Jukun Su, Ankang Liu, et al. (2021). Survival Advantage of Non-hispanic White Patients with Pancreatic Head Carcinoma: A Population-based Study. American Journal of Biomedical and Life Sciences, 9(1), 58-68. https://doi.org/10.11648/j.ajbls.20210901.18

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ACS Style

Hongyu Yu; Chengzhuo Li; Qihui Wu; Jukun Su; Ankang Liu, et al. Survival Advantage of Non-hispanic White Patients with Pancreatic Head Carcinoma: A Population-based Study. Am. J. Biomed. Life Sci. 2021, 9(1), 58-68. doi: 10.11648/j.ajbls.20210901.18

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AMA Style

Hongyu Yu, Chengzhuo Li, Qihui Wu, Jukun Su, Ankang Liu, et al. Survival Advantage of Non-hispanic White Patients with Pancreatic Head Carcinoma: A Population-based Study. Am J Biomed Life Sci. 2021;9(1):58-68. doi: 10.11648/j.ajbls.20210901.18

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@article{10.11648/j.ajbls.20210901.18,
  author = {Hongyu Yu and Chengzhuo Li and Qihui Wu and Jukun Su and Ankang Liu and Qiqi Ke and Qiaohong Yang},
  title = {Survival Advantage of Non-hispanic White Patients with Pancreatic Head Carcinoma: A Population-based Study},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {9},
  number = {1},
  pages = {58-68},
  doi = {10.11648/j.ajbls.20210901.18},
  url = {https://doi.org/10.11648/j.ajbls.20210901.18},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20210901.18},
  abstract = {Numerous studies have shown that racial health disparities in gastroenterology and hepatology, but little is known about its effect on pancreatic head carcinoma (PHC). The aim of the present study was to determine whether racial disparities in the overall survival (OS) and cancer-specific survival (CSS) rates exist among US patients with PHC. The SEER database was searched for US residents who had been diagnosed with PHC from 2007 to 2015. The outcomes for 9724 Hispanic white (HW) patients and their non-Hispanic white (NHW) counterparts were compared using Kaplan-Meier survival and Cox regression analyses. We found that race affected both OS and CSS. The 5-year OS rate was worse for HW patients (45.9%) than for NHW patients (49.6%, P<0.001), as was the 5-year CSS rate (39.8% versus 44.0%, P=0.002). Race appeared to be an independent prognostic factor for PHC in the multivariate analysis, with NHW patients showing superior OS (P=0.007) and CSS (P=0.037) compared with HW patients. Subgroup analysis showed that race influenced survival among patients who received surgery, enjoyed Medicaid, and those at American Joint Committee on Cancer (AJCC) tumor-node-metastasis (TNM) stage II, but not of patients at AJCC TNM stage I, III, or IV and those who did not receive surgery or had no insurance. In short, the survival outcomes for PHC are better for NHW than HW patients. The survival advantage is more skewed towards NHW patients than HW patients with PHC, so culturally appropriate interventions, strengthened preventive services, and additional financial support should focus more on HWs.},
 year = {2021}
}

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TY  - JOUR
T1  - Survival Advantage of Non-hispanic White Patients with Pancreatic Head Carcinoma: A Population-based Study
AU  - Hongyu Yu
AU  - Chengzhuo Li
AU  - Qihui Wu
AU  - Jukun Su
AU  - Ankang Liu
AU  - Qiqi Ke
AU  - Qiaohong Yang
Y1  - 2021/02/02
PY  - 2021
N1  - https://doi.org/10.11648/j.ajbls.20210901.18
DO  - 10.11648/j.ajbls.20210901.18
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 58
EP  - 68
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20210901.18
AB  - Numerous studies have shown that racial health disparities in gastroenterology and hepatology, but little is known about its effect on pancreatic head carcinoma (PHC). The aim of the present study was to determine whether racial disparities in the overall survival (OS) and cancer-specific survival (CSS) rates exist among US patients with PHC. The SEER database was searched for US residents who had been diagnosed with PHC from 2007 to 2015. The outcomes for 9724 Hispanic white (HW) patients and their non-Hispanic white (NHW) counterparts were compared using Kaplan-Meier survival and Cox regression analyses. We found that race affected both OS and CSS. The 5-year OS rate was worse for HW patients (45.9%) than for NHW patients (49.6%, P<0.001), as was the 5-year CSS rate (39.8% versus 44.0%, P=0.002). Race appeared to be an independent prognostic factor for PHC in the multivariate analysis, with NHW patients showing superior OS (P=0.007) and CSS (P=0.037) compared with HW patients. Subgroup analysis showed that race influenced survival among patients who received surgery, enjoyed Medicaid, and those at American Joint Committee on Cancer (AJCC) tumor-node-metastasis (TNM) stage II, but not of patients at AJCC TNM stage I, III, or IV and those who did not receive surgery or had no insurance. In short, the survival outcomes for PHC are better for NHW than HW patients. The survival advantage is more skewed towards NHW patients than HW patients with PHC, so culturally appropriate interventions, strengthened preventive services, and additional financial support should focus more on HWs.
VL  - 9
IS  - 1
ER  -

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Author Information

Hongyu Yu

School of Nursing, Jinan University, Guangzhou, China
Chengzhuo Li

School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, China
Qihui Wu

School of Nursing, Jinan University, Guangzhou, China
Jukun Su

School of Nursing, Jinan University, Guangzhou, China
Ankang Liu

School of Nursing, Jinan University, Guangzhou, China
Qiqi Ke

School of Nursing, Jinan University, Guangzhou, China
Qiaohong Yang

School of Nursing, Jinan University, Guangzhou, China

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APA Style

Hongyu Yu, Chengzhuo Li, Qihui Wu, Jukun Su, Ankang Liu, et al. (2021). Survival Advantage of Non-hispanic White Patients with Pancreatic Head Carcinoma: A Population-based Study. American Journal of Biomedical and Life Sciences, 9(1), 58-68. https://doi.org/10.11648/j.ajbls.20210901.18

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ACS Style

Hongyu Yu; Chengzhuo Li; Qihui Wu; Jukun Su; Ankang Liu, et al. Survival Advantage of Non-hispanic White Patients with Pancreatic Head Carcinoma: A Population-based Study. Am. J. Biomed. Life Sci. 2021, 9(1), 58-68. doi: 10.11648/j.ajbls.20210901.18

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AMA Style

Hongyu Yu, Chengzhuo Li, Qihui Wu, Jukun Su, Ankang Liu, et al. Survival Advantage of Non-hispanic White Patients with Pancreatic Head Carcinoma: A Population-based Study. Am J Biomed Life Sci. 2021;9(1):58-68. doi: 10.11648/j.ajbls.20210901.18

Copy | Download

@article{10.11648/j.ajbls.20210901.18,
  author = {Hongyu Yu and Chengzhuo Li and Qihui Wu and Jukun Su and Ankang Liu and Qiqi Ke and Qiaohong Yang},
  title = {Survival Advantage of Non-hispanic White Patients with Pancreatic Head Carcinoma: A Population-based Study},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {9},
  number = {1},
  pages = {58-68},
  doi = {10.11648/j.ajbls.20210901.18},
  url = {https://doi.org/10.11648/j.ajbls.20210901.18},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20210901.18},
  abstract = {Numerous studies have shown that racial health disparities in gastroenterology and hepatology, but little is known about its effect on pancreatic head carcinoma (PHC). The aim of the present study was to determine whether racial disparities in the overall survival (OS) and cancer-specific survival (CSS) rates exist among US patients with PHC. The SEER database was searched for US residents who had been diagnosed with PHC from 2007 to 2015. The outcomes for 9724 Hispanic white (HW) patients and their non-Hispanic white (NHW) counterparts were compared using Kaplan-Meier survival and Cox regression analyses. We found that race affected both OS and CSS. The 5-year OS rate was worse for HW patients (45.9%) than for NHW patients (49.6%, P<0.001), as was the 5-year CSS rate (39.8% versus 44.0%, P=0.002). Race appeared to be an independent prognostic factor for PHC in the multivariate analysis, with NHW patients showing superior OS (P=0.007) and CSS (P=0.037) compared with HW patients. Subgroup analysis showed that race influenced survival among patients who received surgery, enjoyed Medicaid, and those at American Joint Committee on Cancer (AJCC) tumor-node-metastasis (TNM) stage II, but not of patients at AJCC TNM stage I, III, or IV and those who did not receive surgery or had no insurance. In short, the survival outcomes for PHC are better for NHW than HW patients. The survival advantage is more skewed towards NHW patients than HW patients with PHC, so culturally appropriate interventions, strengthened preventive services, and additional financial support should focus more on HWs.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Survival Advantage of Non-hispanic White Patients with Pancreatic Head Carcinoma: A Population-based Study
AU  - Hongyu Yu
AU  - Chengzhuo Li
AU  - Qihui Wu
AU  - Jukun Su
AU  - Ankang Liu
AU  - Qiqi Ke
AU  - Qiaohong Yang
Y1  - 2021/02/02
PY  - 2021
N1  - https://doi.org/10.11648/j.ajbls.20210901.18
DO  - 10.11648/j.ajbls.20210901.18
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 58
EP  - 68
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20210901.18
AB  - Numerous studies have shown that racial health disparities in gastroenterology and hepatology, but little is known about its effect on pancreatic head carcinoma (PHC). The aim of the present study was to determine whether racial disparities in the overall survival (OS) and cancer-specific survival (CSS) rates exist among US patients with PHC. The SEER database was searched for US residents who had been diagnosed with PHC from 2007 to 2015. The outcomes for 9724 Hispanic white (HW) patients and their non-Hispanic white (NHW) counterparts were compared using Kaplan-Meier survival and Cox regression analyses. We found that race affected both OS and CSS. The 5-year OS rate was worse for HW patients (45.9%) than for NHW patients (49.6%, P<0.001), as was the 5-year CSS rate (39.8% versus 44.0%, P=0.002). Race appeared to be an independent prognostic factor for PHC in the multivariate analysis, with NHW patients showing superior OS (P=0.007) and CSS (P=0.037) compared with HW patients. Subgroup analysis showed that race influenced survival among patients who received surgery, enjoyed Medicaid, and those at American Joint Committee on Cancer (AJCC) tumor-node-metastasis (TNM) stage II, but not of patients at AJCC TNM stage I, III, or IV and those who did not receive surgery or had no insurance. In short, the survival outcomes for PHC are better for NHW than HW patients. The survival advantage is more skewed towards NHW patients than HW patients with PHC, so culturally appropriate interventions, strengthened preventive services, and additional financial support should focus more on HWs.
VL  - 9
IS  - 1
ER  -

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