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3-Sphere Torsional Angles and Six Membered Ring Conformation

The conformation of six membered ring, 1,3,4-tri-o-acetyl-2-azido-6-bromo-2,6-dideoxy-D-galactose α-1 and β-1, and 2,6-dideoxy-2,6-imino- D-talonic acid 2D and L-talonic acid 2L, is analyzed inscribing two five membered ring on six membered ring. Altona’s five membered ring conformational parameters, phase angles of the pseudorotation P1, P2 [deg] and angle of deviation from planarity θm [deg] = f(P [deg]), are calculated with Java Script program using 3-Sphere torsional angles. The correlation between Altona map and six membered ring Stoddart’s diagram conformations was confirmed with VISION molecular models. 3-Sphere torsional angles θnn+1 [deg] for all cis, trans-ee, -aa stereochemistry are disclosed from trigonometric point of view, Hopf fibration confirmed by Lie algebra. The cis, trans stereochemistry on two units with six sets angles ensure relationships between dihedral θHnHn+1 [deg]/vicinal angles ϕ [deg] (θBn + A = θAn, θAn = θHnHn+1, θBn = ϕ), and between dihedral θHnHn+1 [deg]/torsional angles θnn+1 [deg] (θnn+1 = A +/- θHnHn+1); in first case A = 150 for trans-aa6,1 and A = 90 for trans-aa5,2 and trans-ee stereochemistry, in last case A = 180 [deg] for cis and trans-aa stereochemistry and A = 120 [deg] for trans-ee stereochemistry. The number of dihedral angles with positive and negative sign results from 3-sphere approach for only one vicinal coupling constant 3JHnHn+1 [Hz] are restricted by the VISION molecular models.

3-Sphere, Hopf Fibration, Lie Algebra, 6 Membered Ring Conformation, Altona Map, Stoddart’s Diagrams, Carbasugar

APA Style

Emerich Bartha, Carmen-Irena Mitan, Petru Filip. (2023). 3-Sphere Torsional Angles and Six Membered Ring Conformation. American Journal of Quantum Chemistry and Molecular Spectroscopy, 7(1), 9-15. https://doi.org/10.11648/j.ajqcms.20230701.12

ACS Style

Emerich Bartha; Carmen-Irena Mitan; Petru Filip. 3-Sphere Torsional Angles and Six Membered Ring Conformation. Am. J. Quantum Chem. Mol. Spectrosc. 2023, 7(1), 9-15. doi: 10.11648/j.ajqcms.20230701.12

AMA Style

Emerich Bartha, Carmen-Irena Mitan, Petru Filip. 3-Sphere Torsional Angles and Six Membered Ring Conformation. Am J Quantum Chem Mol Spectrosc. 2023;7(1):9-15. doi: 10.11648/j.ajqcms.20230701.12

Copyright © 2023 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

1. C. Altona, M. Sundaralingam, Conformational analysis of the sugar ring in nucleosides and nucleotides. A new description using the concept of pseudorotation, J. Am. Chem. Soc. 1972, 94, 8205; doi.org/10.1021/ja00778a043.
2. A. Navarro-Vazquez, J. C. Cobas, F. J. Sardina, A graphical tool for the prediction of vicinal proton-proton 3JHH coupling constants, J. Chem. Inf. Comput. Sci. 2004, 44, 1690; doi.10.1021/ci049913f.
3. E. Bartha, C.-I. Mitan, C. Draghici, M. T. Caproiu, P. Filip, R. Moriarty, Program for prediction dihedral angle from vicinal coupling constant with 3-sphere approach, Rev. Roum. Chim. 2021, 66, 178-183; DOI: 10.33224/rrch.2021.66.2.08 (Eng).
4. C.-I. Mitan, E. Bartha, P. Filip, C. Draghici, M. T. Caproiu, R. M. Moriarty, Two isomers with trans-aa5,2 stereochemistry are calculated with 3-sphere trigonometric equations approach at circle inversion motion from NMR data. ACS National Meeting in Chicago, IL, August 21- 25, 2022, CARB 3717658, 22 august 2022; doi.org/10.1021/scimeetings.2c00523.
5. C.-I. Mitan, E. Bartha, C. Draghici, M. T. Caproiu, P. Filip, R. M. Moriarty, Hopf fibration on relationship between dihedral angle θHnHn+1 [deg] and vicinal angle ϕ [deg], angles calculated from NMR data with 3-sphere approach and Java Script, Science Journal of Chemistry, SciencePG 2022, 10, 21; DOI: 10.11648/j.sjc.20221001.13 (Eng).
6. J. B. Houseknecht, C. Altona, C. M. Hadad, T. L. Lowary, Conformational Analysis of Furanose Rings with PSEUROT:  Parametrization for Rings Possessing the Arabino, Lyxo, Ribo, and Xylo Stereochemistry and Application to Arabinofuranosides, J. Org. Chem. 2002, 67, 4647; doi.org/10.1021/jo025635q.
7. P. MS Hendrickx, J. C. Martins, A new friendly Matlab program and GUI for the pseudorotation analysis of saturated five membered ring system based on scalar coupling constants, Chemistry Central Journal 2008, 2, 20; doi: 10.1186/1752-153X-2-4.
8. F. H. Cano, C. Forces-Forces, S. Garcia-Blanco, A model for describing the conformation of flexible 6-membered rings. I. Tetrahedron 1977, 33, 797; doi.org/10.1016/0040-4020(77)80195-6.
9. J. C. A. Boeyens, The conformation of six membered rings, J. Cryst. Molec. Struct., 1978, 8 (6), 317; doi 10.1007/BF01200485.
10. C.-I. Mitan, E. Bartha, P. Filip, C. Draghici, M. T. Caproiu, R. M. Moriarty, NMR data on conformational analysis of five and six membered ring under 3-sphere approach. Vicinal constant coupling 3JHH on relationships between dihedral angles and tetrahedral angles. “Sustainability in a changing world” ACS National Meeting in Chicago, IL, August 21- 25, 2022, CARB 3717557, 22 august 2022; doi.org/10.1021/scimeetings.2c00876.
11. X. Biarnés, A. Ardeval, A. Planas, C. Rovira, A. Laio, M. Parrinello, The conformational free energy landscape of β-glucopyranose. Implications for substrate preactivation in β-glucoside hydrolases, J. Am. Chem. Soc. 2007, 129, 10686; Doi: 10.1021/ja068411a.
12. A. R. Ionescu, A. Bérces, M. Z. Zgierski, D. M. Whitfield, T. Nukada, Conformational pathways of saturated six-membered rings. A static and dynamical density functional study, J. Phys. Chem. A 2005, 109, 8096; doi.10.1021/jp052197t.
13. E. Lescrinier, M. Froeyen, P. Herdewijn, Difference in conformational diversity between nucleic acids with a six-membered “sugar” unit and natural “furanose” nucleic acids, Nucleic Acids Research 2003, 31 (12), 2975; Doi: 10.1093/nor/gkg407.
14. Wikipedia: Root system, cube tesseract, Schlafi Hess polygon.
15. C.-I. Mitan, E. Bartha, P. Filip, C. Draghici, M. T. Caproiu, R. M. Moriarty, Manifold inversion on prediction dihedral angle from vicinal coupling constant with 3-sphere approach, Rev. Roum. Chim. 2023, in press.
16. E. Bartha, C.-I. Mitan, C. Draghici, M. T. Caproiu, P. Filip, R. Moriarty, Rectangle as manifold on relationships between vicinal constant couplings 3JHH, 1H and 13C-chemical shifts and dihedral angles, Rev. Roum. Chim., 2022, 67 (3), 167 – 172; DOI: 10.33224/rrch.2022.67.3.05 (Eng).
17. B. M. Malle, I. Lundt, T. M. Wrodnigg, Regioselective intramolecular ring closure of 2-amino-6-bromo-2,6-dideoxyhexano-1,4-lactones to 5- or 6-membered iminuroic acid analogues: synthesis of 1-deoxymannojirimycin and 2.5-dideoxy-2,5-imino-D-glucitol, Organic&Biomolecular Chemistry, 2008, 6, 1779; doi.org/10.1039/B719631H.
18. C.-I. Mitan, E. Bartha, P. Filip, C. Draghici, M. T. Caproiu, R. M. Moriarty, Dihedral angles calculated with 3-sphere approach as integer in conformational analysis on D-, L- ribitol series, Rev. Roum. Chim. 2022, 66 (21), 941, DOI: 10.33224/rrch.2021.66.12.07 (Eng).
19. J. Iglesias-Fernández, L. Raich, A. Ardèval, C. Rovira, The complete conformational free energy landscape of β-xylose reveals a two fold catalytic itinerary for β-xylanases, Chemical Science, 2015, 6, 1167; DOI: 10.1039/c4sc02240h.
20. P. E. Marszalek, Y-P. Pang, H. Li, J. El Yazal, A. F. Oberhauser, J. M. Fernandez, Atomic levers control pyranose ring conformations, Proc. Natl. Acad. Sci. USA, 1999, 96, 7894; doi.org/10.1073/pnas96.14.7894.